Paradigm of modern pharmacology: development and current approaches

The article focuses on the current approach to understanding pharmaceutical products’ effect. It describes a paradigm shift in views on pharmaceutical action in correlation to the processes occurring under pathology. The paper discusses the role of regulatory processes in the development of a disease and a recovery. It points out the necessity of disease registration in order to early start a therap

Pharmacological vector of Rudolf Buchheim

The article is dedicated to the author of experimental pharmacology, professor of University of Dorpat, German pharmacologist Rudolf Buchheim (1820-1879

Charge and Statistics of Quasiparticles in Fractional Quantum Hall Effec

We have studied here the charge and statistics of quasiparticle excitations in FQH states on the basis of the Berry phase approach incorporating the fact that even number of flux quanta can be gauged away when the Berry phase is removed to the dynamical phase. It is observed that the charge $q$ and statistical parameter $\theta$ of a quasiparticle at filling factor $\nu=\frac{n}{2pn+1}$ are given by $q=(\frac{n}{2pn+1})e$ and $\theta=\frac{n}{2pn+1}$, with the fact that the charge of the quasihole is opposite to that of the quasielectron. Using Laughlin wave function for quasiparticles, numerical studies have been done following the work of Kj{\o}nsberg and Myrheim \cite{KM} for FQH states at $\nu=1/3$ and it is pointed out that as in case of quasiholes, the statistics parameter can be well defined for quasielectrons having the value $\theta=1/3$.Comment: 12 pages, 4 figure

Detection of non-Gaussian Fluctuations in a Quantum Point Contact

An experimental study of current fluctuations through a tunable transmission barrier, a quantum point contact, are reported. We measure the probability distribution function of transmitted charge with precision sufficient to extract the first three cumulants. To obtain the intrinsic quantities, corresponding to voltage-biased barrier, we employ a procedure that accounts for the response of the external circuit and the amplifier. The third cumulant, obtained with a high precision, is found to agree with the prediction for the statistics of transport in the non-Poissonian regime.Comment: 4 pages, 4 figures; published versio

Direct Observation of a Fractional Charge

We performed measurements of Quantum Shot Noise in order to determine the quasiparticle charge in the Fractional Quantum Hall regime. The noise is generated by a current flow through a partially transmitting Quantum Point Contact in a 2DEG. The noise is directly proportional to the charge of the quasiparticles, thus allowing direct determination of the charge. We measured Quantum Shot Noise at a filling factor of 1/3 and found that the charge is e/3; as predicted by Laughlin.Comment: 3 pages, PostScript, 4 figures. Submitted to Natur

On the Cooling of Electrons in a Silicon Inversion Layer

The cooling of two-dimensional electrons in silicon-metal-oxide semiconductor field effect transistors is studied experimentally. Cooling to the lattice is found to be more effective than expected from the bulk electron-phonon coupling in silicon. Unexpectedly, the extracted heat transfer rate to phonons at low temperatures depends cubically on electron temperature, suggesting that piezoelectric coupling (absent in bulk silicon) dominates over deformation potential. According to our findings, at 100 mK, electrons farther than 0.1 mm from the contacts are mostly cooled by phonons. Using long devices and low excitation voltage we measure electron resistivity down to 100 mK and find that some of the "metallic" curves, reported earlier, turn insulating below about 300 mK. This finding renders the definition of the claimed 2D metal-insulator transition questionable. Previous low temperature measurements in silicon devices are analyzed and thumb rules for evaluating their electron temperatures are provided.Comment: 5 pages, 4 figures. Discussion corrected and a few references adde